P4532

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P4532

Sigma

 

(−)-N6-(2-Phenylisopropyl)adenosine

solid

Synonym:(R)-N6-(1-Methyl-2-phenylethyl)adenosine, N6-(L-2-Phenylisopropyl)adenosine, R-(−)-PIA
CAS Number:38594-96-6
Linear Formula:C19H23N5O4
Molecular Weight:385.42
EC Number:254-028-5
MDL number:MFCD00069194
PubChem Substance ID:24277681

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Description

Biochem/physiol ActionsA1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

Properties

formsolid
potency1.17 nM Ki for A1 receptors (using [3H]CHA in rat forebrain preparations)
color white
solubilityH2O: 0.3 mg/mL Solutions may be stored for several days at 4°C., slightly soluble
 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL Solutions may be stored for several days at 4°C.
Gene Informationhuman ... ADORA1(134)
storage temp.2-8°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
RTECSAU7404930

References

referenceDaly, J.W. J. Med. Chem. 25, 197, (1982) Abstract
 Bruns, et al. Mol. Pharmacol. 29, 331, (1986) Abstract
 Tan HL, et al. Cardiovasc. Drugs Ther. 13, 441, (1999) Abstract